The hormone cortisol is the principal corticosteroid. Steroids, often referred to as corticosteroids, are hormones produced by the adrenal cortex, the outer part of the adrenal gland. Clinicians are responsible to adjust the prescription dose, frequency and length of treatment based on the procedure performed, the medicine prescribed, and the patient conditions such as age, weight, metabolism, liver and renal function.
NOTE: The pharmacologic management suggestions and sample prescriptions in this handbook represent a general recommendation. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.Chapter 8: Oral Lesions and Corticosteroids
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SWISH SPIT LICENSE
This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). The patient reported no adverse event connected with the use of cyclosporine. The patient was asked to continue the therapy at a dose of 1 mL a day for another month, which resulted in complete resolution of the lesion (Fig. 2) with near complete resolution of the lesion. After 6 weeks of treatment with systemic cyclosporine, there was a dramatic response (Fig. The decision on giving the solution in preference to the capsule was based on the cost effectiveness of the solution and the fact that accurate dosing according to the bodyweight can be achieved by the oral solution. However, there was no significant improvement in the lesions after 5 weeks of therapy, and the patient was then asked to take cyclosporine 200 mg/day orally (1 mL of solution b.d.) mixed with water, milk, or juice (except grape fruit juice) 1 h before meals.
The patient was started on cyclosporine (Psorid Biocon TM) oral solution 100 mg/mL as a “swish and spit” medication, 3 times daily, each treatment lasting for 5 min. Laboratory screen for hepatitis B and C and baseline hemogram, liver function tests, and kidney function tests were within normal limits.
Histopathological examination of the lesion was performed to confirm the diagnosis and to rule out any malignant transformation which was consistent with LP.
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